Anyone else notice a difference with their screen font/size/clarity? It now seems to be slightly out of focus (and no it isn't caused by the beer).
Do I need to adjust something, or just reinstall 7?

Install firefox. I find it much better.

Or Google Chrome.

I use firefox as well. Much better and safer once you get used.

Most websites aren't designed for it. Next to your address bar should be a little pic of a torn page. If you click that you view the site in compatability view which should solve problems. There's also been a recent update on windows update.

Mate use firefox, I'll much prefers it to IE8

I use both and IE8 is excellent when you are used to it.