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Quote ="Durham Giant"Current research on the LAMBDA variant suggests that you are wrong . That variant is already in this country. Fortunately it seems to not be able to bypass Pfizer and Moderna vaccines But allowing pretty much unfettered holiday travel will certainly add to the scientific experiment currently ongoing.
https://www.medrxiv.org/content/10.1101 ... 21259673v1
'"
No it doesn't. The exact opposite in fact. Lambda variant does not completely evade vaccine protection - and this is the Chinese de-activated live virus vaccine. By the way, I didn't say it was impossible, I said it was "highly unlikely".
If you really want to look at this paper in detail they perform no serology - partly because they didn't have access to the Lambda antigen test, they use a pseudo viral neutralisation assay which shows only one part of the immune response, and that response is reduced but not eliminated. It's not a complete picture. You see the same pattern with the delta and the UK variant and that's because the vaccines had the wild type virus as the model. The Lambda variant is the C37 lineage and we make it and supply serology assays for it as a variant of concern. the guys who produced this paper didn't have it.
I would also add that there is complex immune response generated by the vaccines, including T-Cell. The vaccines even seem to generate and immune response to parts of the virus not part of the vaccine itself, and it's not clear why.
I also didn't say we should have unfettered international travel. I didn't mention travel at all.
As for flu, I am acutely aware of how flu mutates, I have worked with vaccine manufacturers to improve their serology and vaccine quantification assays. The group I recently worked with at Oxford are very close to a universal flu vaccine - one shot for life. There are other groups also getting to this point.
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Quote ="Durham Giant"Current research on the LAMBDA variant suggests that you are wrong . That variant is already in this country. Fortunately it seems to not be able to bypass Pfizer and Moderna vaccines But allowing pretty much unfettered holiday travel will certainly add to the scientific experiment currently ongoing.
https://www.medrxiv.org/content/10.1101 ... 21259673v1
'"
No it doesn't. The exact opposite in fact. Lambda variant does not completely evade vaccine protection - and this is the Chinese de-activated live virus vaccine. By the way, I didn't say it was impossible, I said it was "highly unlikely".
If you really want to look at this paper in detail they perform no serology - partly because they didn't have access to the Lambda antigen test, they use a pseudo viral neutralisation assay which shows only one part of the immune response, and that response is reduced but not eliminated. It's not a complete picture. You see the same pattern with the delta and the UK variant and that's because the vaccines had the wild type virus as the model. The Lambda variant is the C37 lineage and we make it and supply serology assays for it as a variant of concern. the guys who produced this paper didn't have it.
I would also add that there is complex immune response generated by the vaccines, including T-Cell. The vaccines even seem to generate and immune response to parts of the virus not part of the vaccine itself, and it's not clear why.
I also didn't say we should have unfettered international travel. I didn't mention travel at all.
As for flu, I am acutely aware of how flu mutates, I have worked with vaccine manufacturers to improve their serology and vaccine quantification assays. The group I recently worked with at Oxford are very close to a universal flu vaccine - one shot for life. There are other groups also getting to this point.
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| Quote ="DHM"Good news, not so good news week.
Not so good news: vaccine breakthrough data compared to initial correlates of protection from Oxford Uni is starting to show that Covid can infect most people who are vaccinated, only 20-25% have sufficient neutralizing antibody response to prevent actual infection.
Good news: Vast majority have an overall antibody response that protects and prevents symptomatic infection (you are infected but don't realise). That particular antibody response can be accurately measured and correlates with severity (or lack of) symptoms. Hardly anyone vaccinated will show severe symptoms. Also it does appear that vaccinated individuals are less likely to infect others due to the lack of viral load developing.
Personally I see this as a warning that "herd immunity" will not be attained with this virus and it will become endemic like the other circulating coronas. I will be continuing to wear masks in shops etc. and take basic precautions, I think everyone should do that for some time for the time being. I don't believe another lockdown makes any sense, but we should all consider basic safe working practices where practical. Would be helpful if the young people dithering got vaccinated as well. It will definitely reduce the spread. Maybe free pizza will do the trick
More good news: studies are underway to test the best booster options. This includes mixing vaccines. One piece of data shows that 2x AZ + a booster from an RNA vaccine (Pfizer or Moderna) gives a really strong response. I have had AZ, would be happy to get Pfizer as a booster.'"
Every single point you made there was made by the scientists 6 months ago. When you say “personally” or “I believe” it’s on the back of what the scientists have already told us so at least give them the credit
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| He is one of the scientists!
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International Star | 1100 | No Team Selected |
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| Quote ="Poky"Every single point you made there was made by the scientists 6 months ago. When you say “personally” or “I believe” it’s on the back of what the scientists have already told us so at least give them the credit'"
Says the ignoramus who can’t even spell Poki correctly
[urlhttps://poki.com/en/g/basketball-stars[/url
But at least Dirty Boris has made sure his Moll has beeb double jabbed with a booster to, dirty old man
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| Talk here (NZ) that Australian (NSW anyway) Kids may not return to their classrooms until January 2022. Cases on the rise and they are well behind the 8 ball (as we are) in terms of vaccinations, so I can see that they will lock down for a month or longer and then vaccinate as many people as possible before going down the UK herd strategy come December....not sure where that leaves us in New Zealand, but I doubt we will have open borders, vaccinated or not, for at least another year.
I think we have 5 years of people being sensible before we will have a chance of normality.....wearing masks, hygiene, distancing etc.....Kids will develop immunity first......this will continue to kill old people but like the flu jab it'll drop the numbers....
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| Quote ="Poky"Every single point you made there was made by the scientists 6 months ago. When you say “personally” or “I believe” it’s on the back of what the scientists have already told us so at least give them the credit'"
All the information I quoted I saw last week. I wasn't making "points" I was sharing information. For example the data for the Pfizer booster was published in the Lancet on the 29th July.
As a published author on Covid I think I qualify to have an opinion also.
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